Kaeng Jed-kwae National Park is situated in an approximately area of 287 square kilometers or 179,375 rai, covering the areas of Kaeng Jed-kwae Forest Park, Kwae-noi National Conserved Forest (Ministerial Regulations No. 704, B.E. 2517) in Tambol Ban-yang, Tambol Kan-chong of Wat-bod District, Pitsanulok Province, Suan-miang National Conserved Forest (Ministerial Regulations No. 1158, B.E. 2529) in Tambol Suan-miang of Charttrakarn District, Pitsanulok Province, Khao-krayang National Conserved Forest (Ministerial Regulations No. 977, B.E. 2525) in Tambol Nhong-krayang, Tambol Ban-yaeng of Nakhon-Thai District, Tambol Ban-klang, Tambol Kaeng-sopa of Wang-thong District, Pitsanulok Province.

Topography
The geographical features of the National Park consist of long mountains and virgin forests.

Flora and Fauna
There are various kinds of forests within the areas of the National Park, including mixed deciduous forests, Deciduous forest, Hill evergreen forests, dry evergreen forests. Major plants, which are of great economic value, include teaks, Afzelia xylocarpa Roxb., Xylia xylocarpa (Deang), Pterocarpus macrocarpus (Pradoo), rubber trees, etc. Wild animals found in the National Park include Muntiacus Muntjak, wild boars, monkeys, langur, masked palm civets, porcupines, rabbits, birds, snakes, monitor lizards, and fish.